The exclusion criteria were concomitant presence of other diseases, including neurologic and neuropsychiatric diseases genetic and metabolic diseases, autoimmune diseases, immunodeficiencies, celiac disease, cancer, adverse food reactions (including ginger allergy) functional gastrointestinal disorders inflammatory bowel diseases liver diseases pancreatic diseases malformations of the gastrointestinal tract infectious diseases other than AGE severe dehydration malnutrition defined as weight‐for‐height <3 standard deviation scores (SDS) previous surgery of the respiratory, gastrointestinal or urinary tract use of gastric acidity inhibitors, antibiotics, antiemetics or other drugs in the 2 weeks before the enrollment use of prebiotics, probiotics or symbiotics in the 2 weeks before the enrollment participation to other studies. The inclusion criteria were age between 1 and 10 years suspected AGE‐related symptoms lasting <12 h: AGE‐associated vomiting (not bilious or bloody) from <4 h modification of stool pattern lasting <12 h mild to moderate dehydration evaluated as described elsewhere.
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Therefore, the present randomised trial was designed to test whether ginger can reduce AGE‐associated vomiting in children. However, many ginger‐based food supplements are increasingly available on the market and are used for the prevention and treatment of vomiting in children without any proof of efficacy. The pharmacological properties of ginger have been investigated mostly in adults, and no data are available on its effects in children. Potential mechanisms of action of ginger include the inhibition of 5‐HT 3 and muscarinic acetylcholine (M3) receptors, and the modulation of esophageal and gastrointestinal motility.
Besides its general anti‐inflammatory action, Given at doses up to 2 g/day, ginger is effective at controlling vomiting without side effects. The antiemetic action of ginger has been investigated in various conditions including motion sickness, pregnancy, post‐anesthesia, post‐surgery, and chemotherapy‐induced nausea and vomiting. The active phenolic compounds of ginger, that is, gingerols, zingiberene and shogaols, have also anti‐inflammatory and anti‐oxidant properties. Ginger ( Zingiber officinale) is a spice with a long history of use as traditional remedy for nausea and vomiting. The antiemetic drugs most frequently prescribed in Europe and Italy are domperidone, a dopamine receptor antagonist, and ondansetron, a 5‐HT 3 antagonist.Ĭurrent evidence shows that ondansetron but not domperidone is effective for the treatment of AGE‐associated vomiting in the emergency setting. Nearly 80% of Italian pediatricians prescribe antiemetic drugs to children with AGE, mostly off‐label. Vomiting is the presenting symptom in up to 75% of children with acute gastroenteritis (AGE), where it contributes to fluid loss, failure of oral rehydration therapy, and emergency admission to the hospital. If you have not already explored it, please click here for more information.Vomiting is a common symptom in childhood and has many causes, ranging from self‐limited to life‐threatening conditions. The Stata Prof+ Plan offers exactly the same products and pricing as the old GradPlan. Norwegian University of Science and Technology
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